the distribution of the anti-hiv drug, tenofovir (pmpa), into the brain, csf and choroid plexuses抗艾滋病药物的分布,泰诺福韦(pmpa),进入大脑,csf和脉络丛.pdf

Cerebrospinal Fluid Research BioMed Central Research Open Access The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses 1 1,2 1 Christy Anthonypillai , Julie E Gibbs and Sarah A Thomas* Address: 1Kings College London, Wolfson Centre for Age-related Diseases, Guys Campus, Hodgkin Building, London SE1 1UL, UK and 2Clinical Neurosciences (Epilepsy Group), St Georges University of London, Cranmer Terrace, London SW17 0RE, UK Email: Christy Anthonypillai - anthonypillai9@; Julie E Gibbs - jgibbs@sghms.ac.uk; Sarah A Thomas* - sarah.thomas@kcl.ac.uk * Corresponding author Published: 03 January 2006 Received: 04 October 2005 Accepted: 03 January 2006 Cerebrospinal Fluid Research 2006, 3:1 doi:10.1186/1743-8454-3-1 This article is available from: /content/3/1/1 © 2006 Anthonypillai et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Tenofovir disoproxil fumarate, a prodrug of the nucleotide reverse transcriptase inhibitor, tenofovir (9-[9(R)-2-(phosphonomethoxy)propyl]adenine; PMPA), was recently approved for use in the combination therapy of human immunodeficiency virus