synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-piperidine or of 4-n-methyl piperazine合成和生物评价的新4,5-disubstituted-thiazolyl酰胺、衍生品4-hydroxy-piperidine或4-n-methyl哌嗪.pdf

Molecules 2003, 8, 472-479 molecules ISSN 1420-3049 Second Eurasian Meeting on Heterocyclic Chemistry “Heterocycles in Organic and Combinatorial Chemistry“ Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine A. Geronikaki *, D. Hadjipavlou-Litina , C. Chatziopoulos and G. Soloupis Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece; Tel. (+30)310997616, Fax (+30)310997612 *Author to whom correspondence should be addressed; e-mail: geronik@pharm.auth.gr Received: 13 May 2003; in revised form: 15 May 2003 / Accepted: 16 May 2003 / Published: 30 June 2003 Abstract: 4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds. Keywords: Thiazolyl amides, anti-inflammatories, antioxidants, lipoxygenase inhibitors. Introduction Various non-steroidal anti-inflammatory drugs (NSAIDs) are in widespread clinical use for