success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of pseudomonas aeruginosa a retrospective study成功率的厚皮移植慢性下肢静脉溃疡取决于一个回顾性研究铜绿假单胞菌的存在.pdf

Success Rate of Split-Thickness Skin Grafting of Chronic Venous Leg Ulcers Depends on the Presence of Pseudomonas aeruginosa: A Retrospective Study 1 2,3 1 1,4 Trine Høgsberg , Thomas Bjarnsholt , Jens Schiersing Thomsen , Klaus Kirketerp-Møller * 1 Copenhagen Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark, 2 Institute for International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, 3 Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark, 4 Orthopedic Department, Hvidovre University Hospital, Copenhagen, Denmark Abstract The last years of research have proposed that bacteria might be involved in and contribute to the lack of healing of chronic wounds. Especially it seems that Pseudomonas aeruginosa play a crucial role in the healing. At Copenhagen Wound Healing Centre it was for many years clinical suspected that once chronic venous leg ulcers were colonized (weeks or months preoperatively) by P. aeruginosa, the success rate of skin grafting deteriorated despite aggressive treatment. To investigate this, a retrospective study was performed on the clinical outcome of 82 consecutive patients with chronic venous leg ulcers on 91 extremities, from the 1st of March 2005 until the 31st of August 2006. This was achieved by analysing the microbiology, demographic data, smoking and drinking habits, diabetes, renal impairment, co-morbidities, approximated size and age of the wounds, immunosuppressive treatment and complicating factors on the clinical outcome of each patient. The results were evaluated using a Student T-test for co