successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen成功解决难治性胃食管返流引起的慢性咳嗽治疗巴氯芬.pdf

Xu et al. Cough 2012, 8:8 /content/8/1/8 Cough CASE REPORT Open Access Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen Xianghuai Xu, Qiang Chen, Siwei Liang, Hanjing LÜ and Zhongmin Qiu* Abstract Gastroesophageal reflux induced cough is a common cause of chronic cough, and proton pump inhibitors are a standard therapy. However, the patients unresponsive to the standard therapy are difficult to treat and remain a challenge to doctors. Here, we summarized the experience of successful resolution of refractory chronic cough due to gastroesophageal reflux with baclofen in three patients. It is concluded that baclofen may be a viable option for gastroesophageal reflux induced cough unresponsive to proton pump inhibitor therapy. Keywords: Baclofen, Chronic cough, Gastroesophageal reflux, Multi-channel intraluminal impedance combined with pH monitoring Introduction radiographs and lung function, negative bronchial Gastroesophageal reflux induced cough (GERC) is a provocation to methacholine, positive IgE specific to common cause of chronic cough and accounts for 5- dust mite and soybean in the serum, 1.5% of eosinophils 41% of chronic cough. [1] Although proton pump inhibi- in induced sputum, normal findings in fiberobroncho- tors are a standard therapy for GERC, some patients do scope, and only submucosal edema with infiltration of not respond to the antireflux medical treatment and re- scattered eosinophils and lymphocytes into airway mu- main a challenge to doctors. Here, we report