balbc mice infected with antimony treatment refractory isolate of leishmania braziliensis present severe lesions due to il-4 productionbalbc小鼠感染治疗难治性锑分离的利什曼虫braziliensis由于il - 4生产出现严重病变.pdf

BALB/c Mice Infected with Antimony Treatment Refractory Isolate of Leishmania braziliensis Present Severe Lesions due to IL-4 Production 1 1 ´ 1 2 1 Diego L. Costa , Vanessa Carregaro , Djalma S. Lima-Junior , Neide M. Silva , Cristiane M. Milanezi , 3 ˆ 4 ´ 5 4 5 Cristina R. Cardoso , Angela Giudice , Amelia R. de Jesus , Edgar M. Carvalho , Roque P. Almeida , ˜ 1* Joao S. Silva ˜ ˜ ˜ 1 Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, 2 Biomedical Sciences Institute, Federal ˆ ˆ ˆ University of Uberlandia, Uberlandia, Brazil, 3 Department of Biological Sciences, Federal University of Triangulo Mineiro, Uberaba, Brazil, 4 Immunology Service, Professor ´ Edgar Santos Universitary Hospital, Federal University of Bahia, Salvador, Brazil, 5 Department of Internal Medicine and Pathology, Federal University of Sergipe, Aracaju, Brazil Abstract Background: Leishmania braziliensis is the main causative agent of cutaneous leishmaniasis in Brazil. Protection against infection is related to development of Th1 responses, but the mechanisms that mediate susceptibility are still poorly understood. Murine models have bee