cd8+ t-cell responses to trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopescd8 + t细胞反应鲁兹锥体高度关注strain-variant trans-sialidase抗原表位.pdf

CD8þ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes 1 1 2 3 4 4¤ Diana L. Martin , D. Brent Weatherly , Susana A. Laucella , Melissa A. Cabinian , Matthew T. Crim , Susan Sullivan , Mark Heiges1 3 1,3 4 5 2 , Sarah H. Craven , Charles S. Rosenberg , Matthew H. Collins , Alessandro Sette , Miriam Postan , Rick L. Tarleton1,4* 1 Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, 2 Instituto Nacional de Parasiologia Dr. Mario Fatala ´ ´ Chaben/Administracion Nacional de Laboratorios e Institutos de Salud ‘‘Dr. Carlos G. Malbran’’ (ANLIS/Malbran), Buenos Aires, Argentina, 3 Department of Microbiology, University of Georgia, Athens, Georgia, United States of America, 4 Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America, 5 La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America CD8þ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of information from viral and bacterial infections, little is known about the antigen specificity or the general development of effector and memory T-cell responses in hosts infected with protozoans. In this study we report on a wide-scale screen for the dominant parasite peptides recognized by CD8þ T cells in T. cruzi–infected mice and