NT-proBNP的全球共识.ppt

Sensitive / specific for HF心力衰竭诊断的敏感性/特异性 Reproduced and standartized across clinical lab.实验室临床检查的重复性及标准化 Easy to perform简便易行 Variations in biomarkers associated with生化标志物的变异性 Variations in clinical status临床情况的变化 Related to interventions与干预措施相关 Variations in prognosis 临床预后的变化 Sensitive / specific for HF 心力衰竭诊断的敏感性/特异性 Reproduced and standartized across clinical lab.实验室临床检查的重复性及标准化 Easy to perform 简便易行 Variations in biomarkers associated with 生化标志物的变异性 Variations in clinical status 临床情况的变化 Related to interventions 与干预措施相关 Variations in prognosis 临床预后的变化 NT-proBNP, troponin T and the effect of coronary revascularization in ACS NT-proBNP，肌钙蛋白T和ACS患者再血管化的效果 James SK, GUSTO-IV substudy. JACC. 2006 NT-proBNP is a strong and independent prognostic indicator in unstable and stable CAD, and is a particularly strong predictor of subsequent HF or death. NT-proBNP是不稳定和稳定性冠状动脉疾病的有力的独立预测因子，特别是对心力衰竭或死亡的预测 Although prospective studies regarding the effect of NT-proBNP measurement in guiding therapy in ischemic heart disease are lacking, among patients presenting with ACS it is recommended to measure NT-proBNP on (or near) the time of admission. An elevated initial NT-proBNP concentration should prompt consideration of an early invasive management approach, particularly if troponin concentrations are also elevated. 尽管缺乏NT-proBNP指导缺血性心脏病治疗的前瞻性研究，在ACS患者中推荐在入院时检测NT-proBNP。基线NT-proBNP浓度升高时应考虑早期介入治疗，特别是合并肌钙蛋白浓度升高时。 Repeat NT-proBNP measurement should be considered after 24-72 hrs and again at 3-6 months as these follow-up measurements provide more long-term prognostic information than single measures at presentation. 应该在24-72小时后以及3-6月后复查NT-proBNP，随访结果比仅在入院时测量更能提供长期预后信息。 Bettencourt P. Heart 2005 Sensitive / specific for HF 心力衰竭诊断的敏感性/特异性 Reproduced and standartized across clinical lab.实验室临床检查的重复性及标准化 Easy to perform 简便易行 Variations in biomarkers associated with 生化标志物的变异性 Variations in clinical status 临床情况的变化 Related to interventions