stem cell therapy for type 1 diabetes mellitus a review of recent clinical trials干细胞治疗1型糖尿病回顾一下最近的临床试验.pdf

Diabetology Metabolic Syndrome BioMed Central Review Open Access Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials Carlos Eduardo Barra Couri* and Júlio César Voltarelli Address: Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil Email: Carlos Eduardo Barra Couri* - ce.couri@.br; Júlio César Voltarelli - jcvoltar@fmrp.usp.br * Corresponding author Published: 16 October 2009 Received: 30 March 2009 Accepted: 16 October 2009 Diabetology Metabolic Syndrome 2009, 1:19 doi:10.1186/1758-5996-1-19 This article is available from: /content/1/1/19 © 2009 Couri and Voltarelli; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Stem cell therapy is one of the most promising treatments for the near future. It is expected that this kind of therapy can ameliorate or even reverse some diseases. With regard to type 1 diabetes, studies analyzing the therapeutic effects of stem cells in humans began in 2003 in the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto - SP USP, Brazil, and since then other centers in different countries started to randomize patients in their clinical trials. Herein we summarize recent data about beta cell regeneratio