stem cell approaches for diabetes towards beta cell replacement糖尿病对β细胞替代干细胞的方法.pdf

Weir et al. Genome Medicine 2011, 3:61 /content/3/9/61 R E V I E W Stem cell approaches for diabetes: towards beta cell replacement Gordon C Weir*, Claudia Cavelti-Weder and Susan Bonner-Weir The problem of diabetes: prospects for Abstract stem-cell-based approaches Stem cells hold great promise for pancreatic beta e promise of stem-cell-derived therapies holds cell replacement therapy for diabetes. In type 1 particularly high hopes for diabetes. e prevalence of diabetes, beta cells are mostly destroyed, and in type both type 1 and type 2 diabetes continues to climb and 2 diabetes beta cell numbers are reduced by 40% to their complications are devastating. In type 1 diabetes, 60%. The proof-of-principle that cellular transplants the beta cells are decimated by autoimmunity and for of pancreatic islets, which contain insulin-secreting unknown reasons the disease is being seen more often. beta cells, can reverse the hyperglycemia of type 1 Type 2 diabetes accounts for over 95% of diabetes cases diabetes has been established, and there is now a worldwide and its increase is mainly caused by the need to nd an adequate source of islet cells. Human encroachment of Western lifestyles of poor diet and lack embryonic stem cells can be directed to become fully of exercise, leading to insulin resistance and obesity. developed beta cells and there is expectation that Advances in genomics and other fields have produced a induced pluripoten