the global landscape of sequence diversity的全球景观序列的多样性.pdf

Volume 8, Issue 11, Article R238Peregrín-Álvarez and Parkinson2007 Open Access Research The global landscape of sequence diversity José Manuel Peregrín-Álvarez*† and John Parkinson*† Addresses: *Molecular Structure and Function, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. †Departments of Biochemistry and Molecular Genetics, 1 Kings College Circle, University of Toronto, Toronto, ON M5S 1A1, Canada. Correspondence: John Parkinson. Email: jparkin@sickkids.ca Published: 8 November 2007 Received: 25 May 2007 Revised: 18 October 2007 Genome Biology 2007, 8:R238 (doi:10.1186/gb-2007-8-11-r238) Accepted: 8 November 2007 The electronic version of this article is the complete one and can be found online at /2007/8/11/R238 © 2007 Peregrín-Álvarez and Parkinson; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. fication of taxon-specific sequences./pSequence diversity across eukaryotes and prokaryotespComparison of genomic and EST sequences reveals a greater genetic diversity within eukaryotes than prokaryotes and enables identi- Abstract Background: Systematic comparisons between genomic sequence datasets have revealed a wide spectrum of sequence specificity from sequences that are highly conserved to those that are specific to individual species. Due to the limited number of fully sequenced eukaryotic genomes,