bloom’s syndrome and pich helicases cooperate with topoisomerase iiα in centromere disjunction before anaphase布鲁姆的综合症和pich解旋酶配合拓扑异构酶iiα在着丝点分裂后期之前.pdf

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIa in Centromere Disjunction before Anaphase ´ 1,2 ` 1,2,3 ´ ` 1,2 4,5,6 Sebastien Rouzeau , Fabrice P. Cordelieres , Geraldine Buhagiar-Labarchede , Ilse Hurbain , 1,2 1,2 7 7 Rosine Onclercq-Delic , Simon Gemble , Laura Magnaghi-Jaulin , Christian Jaulin , Mounira Amor- ´ 1,2* Gueret ˆ ´ 1 Institut Curie, Centre de Recherche, Centre Universitaire, Bat Orsay, France, 2 CNRS UMR3348, Stress Genotoxiques et Cancer, Orsay, France, 3 Institut Curie, Centre de ˆ Recherche, Plateforme d’Imagerie Cellulaire et Tissulaire IBiSA, Centre Universitaire, Bat Orsay, France, 4 Institut Curie, Centre de Recherche, Paris, France, 5 Structure et ´ ´ Compartimentation membranaire, CNRS UMR144, Paris, France, 6 Plateforme d’Imagerie Cellulaire et Tissulaire IBiSA, CNRS UMR 144, Paris, France, 7 Institut de Genetique ´ ´ et Developpement, CNRS UMR 6290, Universite de Rennes 1, Rennes, France Abstract Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of