王延君慢性乙型肝炎患者血脂相关指标检测和临床意义.doc

慢性乙型肝炎患者血脂相关指标检测与临床意义 王延君 李群 杨丽敏 （潍坊医学院传染病学教研室 山东 潍坊 261053） 【摘要】 目的 通过对慢性乙型肝炎(CHB)患者血脂相关指标水平的检测来研究其对肝脏损伤程度的判断。方法 随机选取单纯CHB患者40例，乙型肝炎后肝硬化患者30例，及40例健康对照者（HC）作为研究对象，检测入选研究对象血脂相关指标：甘油三酯（TG）、总胆固醇（CHO）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1（APoA1）、载脂蛋白B100(APoB100)，肝功相关指标：谷丙转氨酶（ALT）、总胆红素（TBiL）。根据检测结果，回顾性分析血脂各项指标与谷丙转氨酶、总胆红素之间的相关性，探讨血脂指标反映肝脏损害程度。结果 单纯慢乙肝、乙型肝炎肝硬化患者的血脂相关指标水平较健康对照者明显降低（p均0.05），分析患病研究对象血清CHO、TG、HDL-C、APoA1、APoB100与血清ALT、TBiL，发现血脂指标与肝功指标有显著的负相关性（P0.05）。结论 慢乙肝患者血脂相关指标水平明显低于健康人群并能反应肝细胞损害程度，加强慢乙肝患者血清TG、CHO等血脂相关指标的的随访检测是有必要的。 【关键词】慢性乙型肝炎，甘油三酯，总胆固醇，载脂蛋白，谷丙转氨酶，总胆红素 Detection of serum lipids of patients with chronic hepatitis B and its clinical significance Wang Yan jun，LI Qun，Yang Limin （Department of Infectious Disease ,Weifang Medical College,Weifang　261053） 【ABSTRACT】 Objective Through detecting the blood lipid related indexes of chronic hepatitis B (CHB) pations to study the judgment of which on the degree of liver injury. Methods randomly selecting 40 patients with pure CHB, 30 patients with liver cirrhosis after hepatitis B, and 40 cases of healthy controls (HC) as the object of study. Than detecting blood lipid indexes related to detection: triglyceride (TG), total cholesterol (CHO), high density lipoprotein (HDL-C), apolipoprotein A1 (APoA1), apolipoprotein B100 (APoB100), relevant indicators of liver function: alanine aminotransferase (ALT), total bilirubin (TBiL). According to the detecting results, a retrospective analysis of the correlation between blood lipid indexes and glutamic pyruvic transaminase, total bilirubin, blood lipid index to reflect the degree of liver injury.Results The blood lipid levels of both pure chronic hepatitis B and cirrhosis of hepatitis B patients made significantly difficulty, they are higher than the blood lipid levels of the healthy control group (P 0.05). Then to analyze the relevance between serum CHO, TG, HDL-C, APoA1, APoB100 and serum ALT, TBiL of pations infected HBV,finding a significant nega