PAI_1基因与纤维蛋白原_链基_省略_性与狼疮性肾炎肾小球微血栓的关系_龚如军.pdf

2002 2 19 1 , 2002, . 19, . 1 Chin J Med Genet February Vol No 1 -1 PAI B 龚如军　刘志红　陈朝红　黎磊石 -1( plasminogen activator inhibitor-1, PAI-1) ( , ) B lupus nephritis LN 101 LN , , : LN ( LN+ T ) 6 ; ( LN- T ) 55 -- 128 ( 1) PAI-1 G/ G G LN+ T ; LN G/ G ( , ) 2. 96, 95% ( , ) : 1. 266. 92; ( 2) odds ratio OR confidence interval CI B G/ A+ A/ A A LN+ T ; LN A OR= 2. , 95% CI: 0. 985. 59; ( 3) LN , , OR= . 5, 95% CI: 1. 3 15. 12; ( 5. 98%) ( -1 / 31. 67% PAI G G B / + / 28. 23%) -1 G A A A LN PAI B , LN ; ; ; ; Genetic variations in plasminogen activator inhibitor-1 gene and B fibrinogen gene associated with * glomerular microthrombosis in lupus nephritis and the gene dosage effect GON G Ruj un, LI U Zhihong, CH EN Zhaohong , L I L eishi. (Research Institute of N ep hrology , Jinling H osp ital, N anj ing Univers ity chool of Medicine, N anj ing, Jiangsu, 210002 P. R. China. E-mail : z hihong@p ublic1.pp t.j s.cn) -1 ( -1) Abstract Objective To explore t he relationship of plasminogen activator inhibitor PAI -675 / 5 - 55 /