dasatinib as a bone-modifying agent anabolic and anti-resorptive effects达沙替尼作为bone-modifying剂合成代谢和anti-resorptive效果.pdf

Dasatinib as a Bone-Modifying Agent: Anabolic and Anti- Resorptive Effects 1,2,3 1,3 1,3 2 ´ Antonio Garcia-Gomez , Enrique M. Ocio , Edvan Crusoe , Carlos Santamaria , Pilar Hernandez- 2 3 2,3 ´ 1 ´ ˜ ´ 4 Campo , Juan F. Blanco , Fermin M. Sanchez-Guijo , Teresa Hernandez-Iglesias , Jesus G. Brinon , 5 6 1,3 ´ 1,2,3 Rosa M. Fisac-Herrero , Francis Y. Lee , Atanasio Pandiella , Jesus F. San Miguel , Mercedes Garayoa1,2,3* ´ ´ 1 Centro de Investigacion del Cancer, IBMCC, Universidad de Salamanca-CSIC, Salamanca, Spain, 2 Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y ´ ´ ´ Leon, Salamanca, Spain, 3 Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain, 4 Departamento de Biologıa Celular y Patologıa, Facultad de Medicina, ´ Universidad de Salamanca, Salamanca, Spain, 5 Servicio de Hematologıa, Hospital General de Segovia, Segovia, Spain, 6 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, United States of America Abstract Background: Bone loss, in malignant or