synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease合成和生物活性评价scutellarein作为一个有效的代理缺血性脑血管疾病的治疗.pdf

Int. J. Mol. Sci. 2011, 12, 8208-8216; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Synthesis and Bio-Activity Evaluation of Scutellarein as a Potent Agent for the Therapy of Ischemic Cerebrovascular Disease Li-Hua Qian 1, Nian-Guang Li 1,2, Yu-Ping Tang 1,*, Li Zhang 1,*, Hao Tang 1, Zhen-Jiang Wang 1, Li Liu 1, Shu-Lin Song 1, Jian-Ming Guo 1 and An-Wei Ding 1 1 Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China; E-Mails: nanzhongyilihua@139.com (L.-H.Q.); linianguang@163.com (N.-G.L.);163.com (H.T.); tianruoxi@126.com (Z.-J.W.); liuli-44@163.com (L.L.); sshl2009@126.com (S.-L.S.); njuguo@ (J.-M.G.); ltcmf@ (A.-W.D.) 2 Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China * Authors to whom correspondence should be addressed; E-Mails: yupingtang@ (Y.-P.T.); zhangliguanxiong@163.com (L.Z.); Tel.: +86-25 Fax: +86-25 Received: 28 June 2011; in revised form: 6 October 2011 / Accepted: 1 November 2011 / Published: 18 November 2011 Abstract: Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, it is very difficult to obtain scutellarein in nature compared with scutellari