tetrahydrofuran cembranoids from the cultured soft coral lobophytum crassum四氢呋喃cembranoids培养的软珊瑚lobophytum crassum.pdf

Mar. Drugs 2011, 9, 2526-2536; doi:10.3390/md9122526 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum Nai-Lun Lee 1,2 and Jui-Hsin Su 1,2,* 1 National Museum of Marine Biology Aquarium, Pingtung 944, Taiwan; E-Mail: love4brat1@.tw 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan * Author to whom correspondence should be addressed; E-Mail: x2219@.tw; Tel.: +886-8-8825001 (ext. 3126); Fax: +886-8-8825087. Received: 9 November 2011; in revised form: 25 November 2011 / Accepted: 28 November 2011 / Published: 7 December 2011 Abstract: Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum . The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines. Keywords: soft coral; Lobophytum crassum ; cembranoids 1. Introduction In the investigation of secondary metabolites from marine invertebrates, several terpenoid metabolites have been isolated from cu