comparison of laryngitis with and without reflux.pdf

GASTROENTEROLOGY jgh_6868 579..585 Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms An Jiang Wang,*,? Mao Jin Liang,? Ai Yun Jiang,? Jin Kun Lin,* Ying Lian Xiao,* Sui Peng,* Jie Chen,* Wei Ping Wen? and Min Hu Chen* Departments of *Gastroenterology and ?Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, and ?Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China Abstract Background and Aim: Little is known about the difference between patients of chronic laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of chronic laryngitis with and without troublesome reflux symptoms. Methods: Consecutive patients with chronic laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryn- goscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring  2 days/week or moderate/severe symp- toms occurring  1 day/week were defined as troublesome reflux symptoms. Results: Compared to patients without troublesome reflux symptoms, those with trouble- some reflux symptoms were older and had more episodes of acid and liquid gastroesoph- ageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P 0.001) and more rapidly (40.8% vs 14.0%, 3 weeks after the start of acid suppression; P = 0.004) compared to those without. Conclusion: Difference in reflux p