Chronic Myloid Leukemia-(慢性粒细胞白血病).pdf

CHRONIC MYELOGENOUS LEUKEMIA Department of HematologyDepartment of Hematology ZhongshanZhongshan HospitalHospital Jenny ZhaoJenny Zhao Introduction •• CML is a CML is a myeloproliferativemyeloproliferative disorder disorder characterized by overproduction of myeloidcharacterized by overproduction of myeloid cells.cells. •• CML occurs chiefly between the ages of 30 CML occurs chiefly between the ages of 30 and 80 yearand 80 year ，，with a peak at 55 years.with a peak at 55 years. and 80 yearand 80 year ，，with a peak at 55 years.with a peak at 55 years. •• The clinical features are The clinical features are splenomegalysplenomegaly and and leukocytosileukocytosi Introduction •• CML is a CML is a clonalclonal bone marrowbone marrow stem cellstem cell disorder in which disorder in which •• CML is a CML is a clonalclonal bone marrowbone marrow stem cellstem cell disorder in which disorder in which a proliferation of maturea proliferation of mature granulocytegranulocyte ((neutrophilneutrophil ,, eosinophileosinophil , and, and basophilbasophil ) and ) and their precursors is found. their precursors is found. The important landmarks in the study of CML were the The important landmarks in the study of CML were the discovery of the Philadelphia (Ph) chromosome and the discovery of the Philadelphia (Ph) chromosome and the characterization of the characterization of the BCRBCR––ABLABL fusion gene.fusion gene. CHRONIC MYELOGENOUS LEUKEMIA • PATHOPHYSIOLOGY •• Clinical featureClinical feature •• Laboratory findingLaboratory finding ••