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smoking during pregnancy and risk of abnormal glucose tolerance a prospective cohort study怀孕期间吸烟和糖耐量异常的风险前瞻性群组研究.pdf

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Haskins et al. BMC Pregnancy and Childbirth 2010, 10:55 /1471-2393/10/55 RESEARCH ARTICLE Open Access Smoking during pregnancy and risk of abnormal glucose tolerance: a prospective cohort study 1,2 2 2 3 2 Amy E Haskins , Elizabeth R Bertone-Johnson , Penelope Pekow , Elena Carbone , Renée T Fortner , Lisa Chasan-Taber2* Abstract Background: Disturbances in glucose metabolism during pregnancy are associated with negative sequalae for both mother and infant. The association between smoking and abnormal glucose tolerance (AGT) remains controversial. Therefore, the aim of this study was to examine the relationship between smoking prior to and during pregnancy and risk of AGT. Methods: We utilized data from a prospective cohort of 1,006 Hispanic (predominantly Puerto Rican) prenatal care patients in Western Massachusetts. Women reported pre- and early pregnancy smoking at recruitment (mean = 15 weeks) and mid pregnancy smoking at a second interview (mean = 28 weeks). AGT was defined as 135 mg/dL on the routine 1-hour glucose tolerance test (1-hr OGTT). We used multivariable regression to assess the effect of pre, early, and mid-pregnancy smoking on risk of AGT and screening plasma glucose value from the 1-hr OGTT. Results: In age-adjusted models, women who smoked 0-9 cigarettes/day in pre-pregnancy had an increased risk of AGT (OR = 1.90; 95% CI 1.02-3.55) compared to non-smokers; this was attenuated in multivariable models. Smoking in early (OR = 0.48; 95% CI 0.21-1.10) and mid pregnancy (OR = 0.38; 95% CI 0.13-1.11) were not associated with AGT in multivariable models. Smoking during early and mid pregnancy were independently associated with lower glucose screening values, while smoking in pre-pr
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