biomarkers of extracellular matrix metabolism (mmp-9 and timp-1) and risk of stroke, myocardial infarction, and cause-specific mortality cohort study细胞外基质代谢的生物标志物(mmp-9和timp-1)和中风的风险,心肌梗塞,死因别死亡率的队列研究.pdf

Biomarkers of Extracellular Matrix Metabolism (MMP-9 and TIMP-1) and Risk of Stroke, Myocardial Infarction, and Cause-Specific Mortality: Cohort Study 1 2,3 ¨ ¨ 4,5 6 1 Jonas Hansson , Ramachandran S. Vasan , Johan Arnlov , Erik Ingelsson , Lars Lind , Anders 2,3 ¨ 7,8 ¨ 1,8 Larsson , Karl Michaelsson , Johan Sundstrom * 1 Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2 Framingham Heart Study, Framingham, Massachusetts, United States of America, 3 Sections of Cardiology and Preventive Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, United States of America, 4 Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden, 5 School of Health and Social Sciences, Dalarna University, Falun, Sweden, 6 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 7 Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 8 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden Abstract Objective: Turnover of the extracellular matrix in all solid organs is governed mainly by a balance between the degrading matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective. Design: The prospective Uppsala Longitudinal Study of Adult Men (ULSAM) cohort, followed from 1991–1995 for up to 18.1 years. A random population-based sample of 1,082