snake venom disintegrins and cell migration蛇毒disintegrins和细胞迁移.pdf

Toxins 2010, 2, 2606-2621; doi:10.3390/toxins2112606 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Review Snake Venom Disintegrins and Cell Migration Heloisa S. Selistre-de-Araujo *, Carmen L. S. Pontes, Cyntia F. Montenegro and Ana Carolina B. M. Martin Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP, 13565-905, Brazil; E-Mails: carmenpontes@.br (C.L.S.P.); cyntia_montenegro@ (C.F.M.); carol_gau@.br (A.C.B.M.M.) * Author to whom correspondence should be addressed; E-Mail: hsaraujo@ufscar.br; Tel.: +55-1633518333; Fax: +55-1633518401. Received: 24 August 2010; in revised form: 15 October 2010 / Accepted: 18 October 2010 / Published: 29 October 2010 Abstract: Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extracellular matrix components, thus playing a central role in cell migration. Integrin clustering at focal adhesions drives actin polymerization along the cell leading edge, resulting in polarity of cell movement. Therefore, small integrin-binding proteins such as the snake venom disintegrins that inhibit integrin- mediated cell adhesion are expected to inhibit cell migration. Here we review the current knowledge on disintegrin and