FoxM1 Increases Urethane-Induced Lung Carcinogenesis.pdf

2011;71:40-50. Published online January 2, 2011.Cancer Res David Balli, Yufang Zhang, Jonathan Snyder, et al. FoxM1 Increases Urethane-Induced Lung Carcinogenesis Specific Deletion of Transcription Factor?Endothelial Cell Updated Version 10.1158/0008-5472.CAN-10-2004doi: Access the most recent version of this article at: Material Supplementary /content/suppl/2010/12/27/71.1.40.DC1.html Access the most recent supplemental material at: Cited Articles /content/71/1/40.full.html#ref-list-1 This article cites 48 articles, 27 of which you can access for free at: E-mail alerts related to this article or journal.Sign up to receive free email-alerts Subscriptions Reprints and .pubs@Publications Department at To order reprints of this article or to subscribe to the journal, contact the AACR Permissions .permissions@Department at To request permission to re-use all or part of this article, contact the AACR Publications American Association for Cancer Research Copyright ? 2011 on October 25, 2012Downloaded from DOI:10.1158/0008-5472.CAN-10-2004 Microenvironment and Immunology Endothelial Cell–Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis David Balli, Yufang Zhang, Jonathan Snyder, Vladimir V. Kalinichenko, and Tanya V. Kalin Abstract Vascular endothelial cells provide essential support to the tumor microenvironment, but little is known about the transcriptional control of endothelial functions during tumorigenesis. Here we define a critical role for the Forkhead transcription factor FoxM1 in modulating the development of tumor-associated endothelial cells. Pulmonary tumorigenesis induced by urethane administration was compared in mice genetically deleted for FoxM1 in endothelial cells (enFoxm1
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mice). Notably, lung tumor number and size were increased in enFoxm1
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mice. Increased tumorigenesis was associated with increased proliferation of tumor cells and increased expression of c-Myc and cycl