tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase ctezosentan-induced衰减endotoxemic羊与肺损伤的蛋白激酶c的激活.pdf

Available online /content/9/3/R211 Vol 9 No 3 Open Access Research Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C 1 1 2 3 4 Vladimir Kuklin , Mikhail Kirov , Mikhail Sovershaev , Thomas Andreasen , Ole C Ingebretsen , Kirsti Ytrehus5 and Lars Bjertnaes6 1Research Fellow, Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Norway 2Research Fellow, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway 3Departmental engineer, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway 4Professor, Department of Clinical Chemistry, University Hospital of Tromsø, Norway 5Professor, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway 6Professor, Chairman of the Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Norway Corresponding author: Lars Bjertnaes, lars.bjertnaes@unn.no Received: 24 Nov 2004 Revisions requested: 9 Jan 2005 Revisions received: 27 Jan 2005 Accepted: 16 Feb 2005 Published: 14 Mar 2005 Critical Care 2005, 9:R211-R217 (DOI 10.1186/cc3497) This article is online at: /content/9/3/R211 © 2005 Kuklin et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Studies in vitro reveal that endothelin-1 (ET-1) interleukin-8 (IL-