comparative genome analysis of the high pathogenicity salmonella typhimurium strain uk-1比较基因组分析高致病性的鼠伤寒沙门氏菌菌株uk-1.pdf

Comparative Genome Analysis of the High Pathogenicity Salmonella Typhimurium Strain UK-1 1,2 1 1 1 1 1 Yingqin Luo , Qingke Kong , Jiseon Yang , Arindam Mitra , Greg Golden , Soo-Young Wanda , 1 3 4 1 Kenneth L. Roland , Roderick V. Jensen , Peter B. Ernst , Roy Curtiss, III * 1 Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, 2 Center for Evolutionary Medicine and Informatics, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, 3 Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, 4 Department of Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, Virginia, United States of America Abstract Salmonella enterica serovar Typhimurium, a gram-negative facultative rod-shaped bacterium causing salmonellosis and foodborne disease, is one of the most common isolated Salmonella serovars in both developed and developing nations. Several S. Typhimurium genomes have been completed and many more genome-sequencing projects are underway. Comparative genome analysis of the multiple strains leads to a better understanding of the evolution of S. Typhimurium and its pathogenesis. S. Typhimurium strain UK-1 (belongs to phage type 1) is highly virulent when orally administered to mice and chickens and efficiently colonizes lymphoid tissues of these species. These characteristics make this strain a good choice for use in vaccine development. In fact