壳聚糖磁性载药微球的研究及性能分析精要.doc

本科学生毕业论文 壳聚糖磁性载药微球的研究及性能分析 黑 龙 江 工 程 学 院 二○一四年六月  The Graduation Thesis for Bachelors Degree Magnetic Chitosan Microspheres Research and Performance Analysis Candidate:Tang Yujia Specialty : Applied Chemistry Class : 10-1 Supervisor:Lecture Wang Xiaodan Heilongjiang Institute of Technology 2014-06·Harbin 摘 要 近些年随着科技的提高，的不能满足需求，壳聚糖Chitosan)能使血液迅速地被凝固，。，、、、等作用以壳聚糖、姜黄素、磁流体为原料采用复乳化法磁性载药壳聚糖微球。最后对磁性壳聚糖载药微球的磁性药物缓释进行研究。 实验表明最佳反应条件是壳聚糖醋酸溶液的浓度为1.5%，适量的姜黄素和磁流体，乳化剂的量是壳聚糖醋酸溶液的20%液体石蜡为200%，交联剂为50%,转速300r/min反应温度在60℃时反应2h得粒径均匀的黄色的沉淀，即壳聚糖磁性载药微球，其外貌光滑，粒径在10~20μm之间，能在较长的时间里进行药物缓释，时间长达6小时以上。 关键词：壳聚糖；磁流体；姜黄素；载药微球；药物缓释 ABSTRACT In recent years with the improvement of peoples living standards and technology，common drugs have been unable to meet human needs，therefore，on this basis，scientists have studied the novel drug.Chitosan blood can be rapidly solidified， we usually use it to stop the bleeding. Because of its biocompatible so you can use it as a landfill wounds，It can also destroy bacteria and accelerate wound improved,swallowed secretions，interference and other effects from water，MHD is the use of Fe3+ and Fe2+ under alkaline conditions in preparation for.Chitosan,curcumin，magnetic fluid as raw materials using a complex emulsion cross linking method to obtain magnetic chitosan microspheres containing the drug，finally，the magnetic Chitosan microspheres magnetic morphology，drug delivery research. Experiments show that The optimal reaction conditions for the concentration of chitosan was 1.5% acetic acid solution and the right amount of curcumin and magnetic fluids，the amount of emulsifier is 20% of chitosan acetic acid solution,liquid paraffin was 200%，crosslinking agent is 50%，the speed of 300 r/min，the reaction temperature of the reaction have a uniform particle size of the yellow precipitate 2h at 60℃，the chitosan magnetic carrier drug microsphere is.Its appearance is smooth，particle size between 10~20μm，the drug release can be a long time，he time up to more than six hours.