核磁共振技术在生物研究中的应用_姜凌.pdf
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姜 凌 刘买利
( 430071)
( nuclear magnetic resonance, MR) .
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Nuclear magnetic resonance applications in biological systems
JIA G Ling LIU MaiLi
(StateK ey laboratory of Magnetic Resonance and A tomic and M olecular Physics,
Wuhan Institute of Physics and Mathematics, ChineseAcademy of Sciences, Wuhan 430071, China)
Abstract uclear magnetic resonance ( MR) spectroscopy is a stateoftheart technology which has
been widely applied in biological systems over the past decades. It is a powerful tool for macromolecular
structure determination in solution, and has the unique advantage of being capable of elucidating the struc
ture and dynamic behavior of proteins during vital biomedical processes. In thisreview, we introduce the re
cent progress in MR techniques for studying the structure, interaction and dynamics of proteins. The
methods for MR based drug discovery and metabonomics are also briefly introduced.
Keywords nuclear magnetic resonance( MR) ,protein solution structure, protein dynamics, drug screen
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2011- 02- 28
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