宿主免疫反应在暴发性肝功能衰竭发病机制中的作用（The role of host immune response in the pathogenesis of fulminant liver failure）.doc

宿主免疫反应在暴发性肝功能衰竭发病机制中的作用（The role of host immune response in the pathogenesis of fulminant liver failure） The role of host immune response in the mechanism of sudden liver failure Sudden liver failure is a clinical syndrome that causes severe liver dysfunction in the short term of liver cells due to a variety of causes, rapid progression of disease, high death rate and poor prognosis. The pathogenesis of the disease is complicated and it is still not clear. Current research suggests, can be roughly divided into two aspects, one is the direct damage of pathogen (cause), secondly, the host immune response caused by excessive activation of damage, including various mobilization of immune cells and cytokines. The role of host immune response in the pathogenesis of fulminant liver failure is described in this paper. The role of natural immunity in fulminant liver failure 1. Monocytes and macrophages: natural immunity is the first line of defense of the human body, and rapid response to injury has played an important role in the development of sudden liver failure. Monocytes and macrophages play a key role as an important component of natural immunity. After the liver has been damaged, the liver cells and macrophages release chemokine to make monocytes and macrophages from the bone marrow to the liver and activate. Monocyte chemotactic protein 1 (monocyte chemoattractant protein 1, MCP - 1), macrophage inflammatory protein (macrophage inflammatory protein, MIP) belongs to the members of the family of C - C chemokines, through expression on monocytes, macrophages chemokine receptors on the surface of the [chemokine receptor (C - C motif), CCR] work. Leifeld et al. found that the serum McP-1, mip-1a and mip-1 beta were significantly higher in patients with sudden liver failure than in patients with chronic liver disease and healthy controls. In with sword bean globulin (concanavalin - A, ConA) and A galactosamine (galactosamine, GaIN)/lipopolysaccharide (LPS) lipopolysacchar