Effect of Angelica sinensis polysaccharides on airway epithelial repair after injury.pdf

P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(12):2786-2790 Fax: +86-10 World Journal of Gastroenterology E-mail: wjg@ Copyright ? 2003 by The WJG Press ISSN 1007-9327 ? BASIC RESEARCH ? Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats Shao-Ping Liu, Wei-Guo Dong, Dong-Fang Wu, He-Sheng Luo, Jie-Ping Yu Shao-Ping Liu, Wei-Guo Dong, He-Sheng Luo, Jie-Ping Yu, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China Dong-Fang Wu, Department of Pharmacy, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China Supported by key Project in Scientific and Technological Researches of Hubei Province, No. 2001AA308B Correspondence to: Professor Wei-Guo Dong, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China. dongwg@ Telephone: +86-27Received: 2003-06-05 Accepted: 2003-09-18 Abstract AIM: To study the effect of angelica sinensis polysaccharide (ASP) on immunological colon injury and its mechanisms in rats. METHODS: Immunological colitis model of rats was induced by intracolon enema with 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) and ethanol. The experimental animals were randomly divided into normal control, model control, 5- aminosalicylic acid therapy groups and three doses of ASP therapy groups. The 6 groups were treated intrac