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Temporal Pattern of ICAM-I Mediated Regulatory T Cell Recruitment to Sites of Inflammation in Adoptive Transfer Model of Multiple Sclerosis 1. ¨ 2. 1 2 3 Sebastian Doerck , Kerstin Gobel , Gesa Weise , Tilman Schneider-Hohendorf , Michael Reinhardt , 3 2 4 ¨ 5 1,2,6 2 Peter Hauff , Nicholas Schwab , Ralf Linker , Mathias Maurer , Sven G. Meuth , Heinz Wiendl * 1 Department of Neurology, University of Wuerzburg, Wuerzburg, Germany, 2 Department of Neurology – Inflammatory Disorders of the Nervous System and Neurooncology, University of Muenster, Muenster, Germany, 3 Research Laboratories, Schering AG, Berlin, Germany, 4 Department of Neurology, University of Erlangen, Erlangen, Germany, 5 Caritas Hospital Bad Mergentheim, Bad Mergentheim, Germany, 6 Institute of Physiology I – Neuropathophysiology, Muenster, Germany Abstract Migration of immune cells to the target organ plays a key role in autoimmune disorders like multiple sclerosis (MS). However, the exact underlying mechanisms of this active process during autoimmune lesion pathogenesis remain elusive. To test if pro-inflammatory and regulatory T cells migrate via a similar molecular mechanism, we analyzed the expression of different adhesion molecules, as well as the composition of infiltrating T cells in an in vivo model of MS, adoptive transfer experimental autoimmune encephalomyelitis in rats. We found that the upregulation of ICAM-I and VCAM-I parallels the development of clinical disease onset, but persists on elevated levels also in the phase of clinical