the effect of transdermal delivery of fentanyl on activity in growing pigs皮肤的影响交付芬太尼在生长猪活动.pdf

Acta vet. scand. 2005, 46, 149-157. The Effect of Transdermal Delivery of Fentanyl on Activity in Growing Pigs By L. M. Malavasi, H. Augustsson, M. Jensen-Waern, G. Nyman Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. Malavasi LM, Augustsson H, Jensen-Waern M, Nyman G: The effect of transder- mal delivery of fentanyl on activity in growing pigs. Acta vet. scand. 2005, 46, 149- 157. – Recently, decreased activity levels have been observed in pigs treated postopera- tively with transdermal delivery of fentanyl (TD-fentanyl) after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 µg h-1 on the activity level with and without isoflurane anaesthesia. Eight pigs (25.4 ± 5.2 kg) were submitted to a cross-over study and given two treatments; 1) fentanyl patch applied after 30 minutes of anaesthesia (treatment A/F) and 2) fentanyl patch without anaesthesia (treatment F). The pigs behaviour was observed from a video recording instantaneously every 10 minutes for 24 h before treat- ments and up to 72 h after the patch attachment. Venous blood samples were taken 1, 6, 12, 24, 48 and 72 h after the patch application. The behaviour recordings showed that TD-fentanyl did not produce sedation in any pig. No differences were found between the two treatments in activity level, weight gain or serum fentanyl concentration. This con- centration measured after 24 h was 0.27 ± 0.11 ng ml-1 and 0.47 ± 0.40 ng ml-1 in the A/F and F group, respectively.