营养与肿瘤表观遗传学关系的研究进展DNA甲基化机制-US.PDF

95 21 1 Vol. 21 No. 1 2008 1 Journal ofMedical Postgraduates Jan. 2008 营养与肿瘤表观遗传学关系的 研究进展 DNA 甲基化机制 腾丽娟, 张长松; 李 克 (, 515041) : NA , ; NA , : ,, , : ; ; NA : R735. 1 : A : 1008-8199( 2008) 01-0095-03* R elationsh ip of nu trition w ith cancer and its ep igenetic DNA m ethylation m echan ism TENG L-i juan, ZHANG Chang-song rev iew ing, LIKechecking (D ep artm ent of M olecular Ep idem iology, Shan tou Univ ersity M edical College, Shantou 515041, Guang- dong, China Abs tract: NA methylation is the best studied ofthe epigenetic changes that influence the gene expres- sion, and changes in genom icm ethylation patterns have been observed inmany cancer cell lines. Nutr-i ents asm ethyldonors play essential roles in NA methylation and may modify cancer risk. This review, w ith an emphasis on the relationship between nutrition, NA methylation and cancer, firstly defines methylationw ith a description of its correlatedm echanism, then approaches themolecularmechanism of cancer initiation and development at themethylation level, and lastly summarizes themechanism underly- ing the effect ofmethylation-related nutrients on the process of cancer initiation and development at the molecular leve.l It also offers some suggestions on cancer prevention at the group nutrition level. K ey w ord s: Nutrition; Cancer; NA methylation NA, () 0 [ 1] NA ( epigenetics) 1942W ad-