synthesis of methacrylate monomers with antibacterial effects against s. mutans合成的甲基丙烯酸酯单体对变异链球菌的抗菌效果.pdf

Molecules 2011, 16, 9755-9763; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans Jingwei He 1,2,3,*, Eva Söderling 4, Monica Österblad 5, Pekka K. Vallittu 1,2 and Lippo V. J. Lassila 1,2 1 Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland 2 Turku Clinical Biomaterials Centre-TCBC, University of Turku, Turku 20520, Finland 3 College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China 4 Institute of Dentistry, University of Turku, Turku 20520, Finland 5 Antimicrobial Resistance Unit, National Institute for Health and Welfare, Turku 20520, Finland * Author to whom correspondence should be addressed; E-Mail: hejin@utu.fi. Received: 18 October 2011; in revised form: 21 November 2011 / Accepted: 22 November 2011 / Published: 23 November 2011 Abstract: A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methac