biomedical compounds from marine organisms从海洋生物的生物化合物.pdf

Mar. Drugs 2004, 2, 123-146 Marine Drugs ISSN 1660-3397 /marinedrugs/ Review Biomedical Compounds from Marine organisms Rajeev Kumar Jha 1,* and Xu Zi-rong 2 1 Ph. D. scholar, College of Animal Sciences, Zhejiang University, Hangzhou-310029, P. R. of China, Tel. (+86) 571 Fax. (+86) 571 2 Director, College of Animal Sciences, Zhejiang University, Hangzhou-310029, P.R. of China * Author to whom all correspondence should be addressed: e-mail: jha_fish@yahoo.co.in, rajeev@ Received: 17 May 2004 / Accepted: 1 August 2004 / Published: 25 August 2004 Abstract: The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome (AIDS), arthritis, etc., while other compounds have been developed as analgesics or to treat inflammation, etc. The life- saving drugs are mainly found abundantly in microorganisms, algae and invertebrates, while they are scarce in vertebrates. Modern technologies have opened vast areas of research for the extraction of biomedical compounds from oceans and seas. Key Words: Biomedical compounds, ocean, anti-cancer metabolite, anti-HIV metabolite Mar. Drugs 2004, 2 124 Introduction Marine bio