文献_Identification+of+new+ALK+and+RET+gene+fusions+from+colorectal+and+lung+cancer+biopsies.pdf

B r i e f com m u n i c at i o n s Identification of new ALK and Among 40 CRCs, we identified 125 alterations in 21 genes. We found at least one alteration in 39 out of 40 tumors (with a range of 1–9 altera- RET gene fusions from colorectal tions), and 62.5% (25 out of 40) of the tumors harbored at least two classes of DNA alteration (Fig. 1 and Supplementary Table 3). TP53 and and lung cancer biopsies APC were altered in 80% (32 out of 40) and 67.5% (27 out of 40) of CRCs, respectively, with both being mutated at higher frequencies than are 1,9 2,9 1 1 Doron Lipson , Marzia Capelletti , Roman Yelensky , reported in the Catalogue of Somatic Mutations in Cancer . Additionally, 1 1 1 1 11 genes were mutated, amplified or rearranged in multiple CRCs: Geoff Otto , Alex Parker , Mirna Jarosz , John A Curran , 1 1 1 KRAS (10), BRAF (6), FBXW7 (5), ATM (2), BCL2L1 (2), BRCA2 (2), Sohail Balasubramanian , Troy Bloom , Kristina W Brennan , 1 1 1 CDH1 (2)