文献_KIF5B-RET+fusions+in+lung+adenocarcinoma.pdf

B r i e f com m u n i c at i o n s KIF5B-RET fusions in lung 10p11.2 and RET on chromosome 10q11.2 in subject BR0020 (Fig. 1 and Supplementary Fig. 1a). We then further investigated this fusion, adenocarcinoma as fusions between RET and genes other than KIF5B have previously been shown to drive papillary thyroid tumor formation6,7. 1,15 2,15 3 RT-PCR and a Sanger sequencing analysis of 319 LADC specimens Takashi Kohno , Hitoshi Ichikawa , Yasushi Totoki , 4 4 4 from Japanese individuals (Supplementary Table 2), including 30 that Kazuki Yasuda , Masaki Hiramoto , Takao Nammo , 2 5 5 1 had been subjected to whole-transcriptome sequencing, revealed that Hiromi Sakamoto , Koji Tsuta , Koh Furuta , Yoko Shimada , 6 1 6 7 1.9% (6 out of 319) expressed KIF5B-RET fusion transcripts (Fig. 1b Reika Iwakawa , Hideaki Ogiwara , Takahiro Oike , Masato Enari , 8 6,8 9 9 and Supplementary Fig. 1b). We identified four variants in these six Aaron J Schetter , Hirokazu Okayama , Aage Haugen , Vidar Skaug , 10 11 3