92-gene molecular profiling in identification of cancer origin a retrospective study in chinese population and performance within different subgroups92 -基因分子分析识别癌症的起源的回顾性研究中国人口和性能在不同的子组.pdf

92-Gene Molecular Profiling in Identification of Cancer Origin: A Retrospective Study in Chinese Population and Performance within Different Subgroups 3. 1,2,4. 1,2,4 3 3 3 3 1,2,4 Fei Wu , Dan Huang , Lisha Wang , Qinghua Xu , Fang Liu , Xun Ye , Xia Meng , Xiang Du * 1 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China, 2 Department of Oncology, Shanghai Medical College, Fudan ´ University, Shanghai, People’s Republic of China, 3 Institut Merieux Laboratory, Fudan University Shanghai Cancer Center, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China, 4 Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China Abstract Background: After cancer diagnosis, therapy for the patient is largely dependent on the tumor origin, especially when a metastatic tumor is being treated. However, cases such as untypical metastasis, poorly differentiated tumors or even a limited number of tumor cells may lead to challenges in identifying the origin. Moreover, approximately 3% to 5% of total solid tumor patients will not have to have their tumor origin identified in their lifetime. The THEROS CancerTYPE IDH is designed for identifying the tumor origin with an objective, rapid and standardized procedure. Methodology and Principal Findings: This is a blinded retrospective study to evaluate performance of the THEROS CancerTYPE IDH in a Chinese population. In total, 184 formalin-fixed paraffin-embedded (FFPE) samples of 23 tumor origins were collected from the