酮咯酸氨丁三醇注射液治疗急性胆绞痛疗效观察.doc

酮咯酸氨丁三醇注射液治疗急性胆绞痛疗效观察[摘要] 目的：观察酮咯酸氨对胆绞痛患者的疗效及不良反应。方法：将180例患者随机分为3组，分别应用酮咯酸氨丁三醇（治疗组）、奈福泮（对照组1）和盐酸哌替啶（对照组2）进行肌内注射，观察比较三种药物的镇痛效果及不良反应。结果：酮咯酸氨丁三醇在镇痛效果与盐酸哌替啶比较，无显著性差异，但优于奈福泮。不良反应比较，酮咯酸氨丁三醇与奈福泮无显著性差异；两者与盐酸哌替啶比较，均有显著性差异，且副作用小。结论：酮咯酸氨丁三醇治疗急性胆绞痛时，镇痛疗效确切，不良反应少，值得临床推广。 [关键词] 酮咯酸氨丁三醇；胆绞痛；奈福泮；盐酸哌替啶 [中图分类号] R575.6[文献标识码]B [文章编号]1673-7210（2010）10（a）-045－０2 Efficacy observation on Ketorolac tromethamine Injection in treatment patients with gallstone colic FAN Xiaoyong, FU Ming (Department of Emergency, the Centrａl Hospital of Xinxiang City, Xinxiang 453000, China) [Abstract] Objective: To observe efficacy and adverse reactions of Ketorolac tromethamine in treatment patients with gallstone colic. Methods: 180 patients were randomly divided into 3 groups, application of Ketorolac tromethamine (the treatment group), Nefopam (control group 1) and Pethidine hydrochloride(control group 2) for intramuscular injection, observed and compared the three drugs in the analgesic effect and adverse reactions. Results: There was no difference between Ketorolac tromethamine and Pethidine hydrochloride hudrochloried in analgesic effect but excelling Nefopam. Comparison of adverse reactions, Ketorolac tromethamine was the same as Nefopam, but the two more significant with acceptable side effects compared with Pethidine hydrochloride. Conclusion: Ketorolac tromethamine is worth popularizing for its effective analgesia in treatment acute biliary gallstone colic , and less adverse reactions. [Key words] Ketorolac tromethamine; Gallstone colic; Nefopam;Pethidine hydrochloride 急性胆绞痛是急诊科临床上常见的急腹症之一，因其发病急，疼痛剧烈使患者遭受极大痛苦，及时止痛是急诊患者的首要问题。我科自2007年以来采用酮咯酸氨丁三醇作为主要止痛手段，并与奈福泮和盐酸哌替啶肌内注射进行了对比，现总结报道如下： 1 资料与方法 1.1 一般资料 收集2007年1月～2010年3月我科收治的180例急性胆绞痛患者。随机分为酮咯酸氨丁三醇组60例，奈福泮组60例及盐酸哌替啶组60例。其中，男101例，女59例，最小年龄19岁，最大59岁，平均（33.2±16.2）岁，三组一般资料比较，无显著性差异（P＞0.05），具有可比性。 1.2 方法 对就诊的急诊患者一旦确诊后，治疗组立即采用酮咯酸氨丁三醇注射液60 mg，肌内注射；对照组1立即采用奈福泮20 mg，肌内注射；对照组2立即采用盐酸哌替啶100 mg，肌内注射。同时给予广谱抗生素控制感染，纠正水电解质和酸碱平衡失调等