the effect of spinal manipulative therapy on experimentally induced pain a systematic literature review脊髓操纵的影响治疗实验诱导疼痛系统的文献回顾.pdf

Millan et al. Chiropractic Manual Therapies 2012, 20:26 /content/20/1/26 CHIROPRACTIC MANUAL THERAPIES SYSTEMATIC REVIEW Open Access The effect of spinal manipulative therapy on experimentally induced pain: a systematic literature review Mario Millan1,2*, Charlotte Leboeuf-Yde2,3,4, Brian Budgell5 and Michel-Ange Amorim1,6 Abstract Background: Although there is evidence that spinal manipulative therapy (SMT) can reduce pain, the mechanisms involved are not well established. There is a need to review the scientific literature to establish the evidence-base for the reduction of pain following SMT. Objectives: To determine if SMT can reduce experimentally induced pain, and if so, if the effect is i) only at the level of the treated spinal segment, ii) broader but in the same general region as SMT is performed, or iii) systemic. Design: A systematic critical literature review. Methods: A systematic search was performed for experimental studies on healthy volunteers and people without chronic syndromes, in which the immediate effect of SMT was tested. Articles selected were reviewed blindly by two authors. A summary quality score was calculated to indicate level of manuscript quality. Outcome was considered positive if the pain-reducing effect was statistically significant. Separate evidence tables were constructed with information relevant to each research question. Results were interpreted taking into account their manuscript quality. Results: Twenty-two articles were included, describing 43 experiments, primarily on pain produced by pressure (n = 27) or temperature (n = 9). Their quality was generally moderate. A hypoalgesic effect was shown in 19/27 experiments on pressure pain, produced by pressure in 3/9 on pain produced by temperature