single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients a systematic review单一药物疗法或选择性净化消化道的预防性抗真菌治疗危重病人系统回顾.pdf

Available online /content/11/6/R126 Vol 11 No 6 Open Access Research Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review 1 1 1 1 2 JW Olivier van Till , Oddeke van Ruler , Bas Lamme , Roy JP Weber , Johannes B Reitsma and Marja A Boermeester1 1Department of Surgery, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands 2Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Room J1b-208, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands Corresponding author: Marja A Boermeester, m.a.boermeester@amc.uva.nl Received: 26 Jun 2007 Revisions requested: 2 Aug 2007 Revisions received: 16 Aug 2007 Published: 7 Dec 2007 Critical Care 2007, 11:R126 (doi:10.1186/cc6191) This article is online at: /content/11/6/R126 © 2007 van Till et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The objective of this study was to determine and OR 0.54, 95% CI 0.39 to 0.75; SDD: OR 0.29, 95% CI 0.18 to compare the effectiveness of different prophylactic antifungal 0.45). Treatment effects were significantly larger in SDD trials therapies in critically ill patients on the incidence of yeast than in SAP trials. The incidence of candidemia was reduced by colonisation,