systematic review of dexketoprofen in acute and chronic pain系统回顾dexketoprofen的急性和慢性疼痛.pdf

BMC Clinical Pharmacology BioMed Central Research article Open Access Systematic review of dexketoprofen in acute and chronic pain † † R Andrew Moore* and Jodie Barden Address: Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK Email: R Andrew Moore* - andrew.moore@pru.ox.ac.uk; Jodie Barden - jodie.barden@balliol.ox.ac.uk * Corresponding author †Equal contributors Published: 31 October 2008 Received: 25 March 2008 Accepted: 31 October 2008 BMC Clinical Pharmacology 2008, 8:11 doi:10.1186/1472-6904-8-11 This article is available from: /1472-6904/8/11 © 2008 Moore and Barden; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review. We used published and unpublished information from randomised clinical trials (RCTs) of dexketoprofen in painful conditions to assess evidence on efficacy and harm. Methods: PubMed and Cochrane Central were searched for RCTs of dexketoprofen for pain of an