upregulation of leukotriene receptors in gastric cancerupregulation白三烯受体在胃癌.pdf

Cancers 2011, 3, 3156-3168; doi:10.3390/cancers3033156 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Upregulation of Leukotriene Receptors in Gastric Cancer Marino Venerito 1, Doerthe Kuester 2, Caroline Harms 1, Daniel Schubert 3, Thomas Wex 1,* and 1 Peter Malfertheiner 1 Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Leipziger Str. 44, Magdeburg 39120, Germany; E-Mails: m.venerito@med.ovgu.de (M.V.); caroline.harms@web.de (C.H.); peter.malfertheiner@med.ovgu.de (P.M.) 2 Institute of Pathology, Otto-von-Guericke University, Leipziger Str. 44, Magdeburg 39120, Germany; E-Mail: doerthe.kuester@med.ovgu.de 3 Department of General, Visceral and Vascular Surgery, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, Magdeburg 39120, Germany; E-Mail: daniel.schubert@med.ovgu.de * Author to whom correspondence should be addressed; E-Mail: thomas.wex@med.ovgu.de; Tel.: +49-391-6713106; Fax: +49-391-6713105. Received: 10 June 2011; in revised form: 2 August 2011 / Accepted: 4 August 2011 / Published: 8 August 2011 Abstract: Background : Leukotrienes (LT) mediate allergic and inflammatory processes. Previously, we identified significant changes in the expression pattern of LT receptors in the gastric mucosa after eradication of Helicobacter pylori infection. The aim of the present study was to evaluate the expression of 5-lipoxygenase (5-LOX) and LT receptors in gastric cancer (GC). Methods: The expression of 5-LOX and recept