the association of 25-hydroxyvitamin d3 and d2 with behavioural problems in childhood人体内25 -羟维生素d3的协会和d2与儿童行为问题.pdf

The Association of 25-Hydroxyvitamin D3 and D2 with Behavioural Problems in Childhood 1 2 3 2 2,4 Anna-Maija Tolppanen , Adrian Sayers , William D. Fraser , Glyn Lewis , Stanley Zammit , Debbie A. Lawlor1* 1 Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 2 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 3 Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 4 Medical Research Council Centre Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom Abstract Background: Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D3 (the active vitamin D3 metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans. Methods: We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D and 25(OH)D – 3 2 and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D3 and 25(OH)D2 concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Dif