the first sequenced carnivore genome shows complex host-endogenous retrovirus relationships第一个食肉动物基因组测序显示复杂host-endogenous逆转录病毒的关系.pdf

The First Sequenced Carnivore Genome Shows Complex Host-Endogenous Retrovirus Relationships ´ ´ 1 2 1 2,3 ¨ 4 Alvaro Martınez Barrio , Marie Ekerljung , Patric Jern , Farid Benachenhou , Goran O. Sperber , Erik 2,5 3 ¨ 2 Bongcam-Rudloff , Jonas Blomberg , Goran Andersson * 1 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, 2 Department of Animal Breeding and Genetics, Biomedical Centre, Swedish University of Agricultural Sciences, Uppsala, Sweden, 3 Section of Virology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4 Department of Neuroscience, Physiology, Uppsala University, Uppsala, Sweden, 5 Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden Abstract Host-retrovirus interactions influence the genomic landscape and have contributed substantially to mammalian genome evolution. To gain further insights, we analyzed a female boxer (Canis familiaris) genome for complexity and integration pattern of canine endogenous retroviruses (CfERV). Intriguingly, the first such in-depth analysis of a carnivore species identified 407 CfERV proviruses that represent only 0.15% of the dog genome. In comparison, the same detection criteria identified about six times more HERV proviruses in the human genome that has been estimated to contain a total of 8% retroviral DNA including solitary LTRs. These observed differences in man and dog are likely due to different mechanisms to purge, restrict and protect their genomes against retroviruses. A novel group of gammaretrovirus-like CfERV