预防乙型肝炎病毒再激活.ppt

预防乙型肝炎病毒再激活

HBV再激活旳发生

HepatitisB:SomeSoberingFacts350millionpeoplechronicallyinfected2billionwithevidenceofpastorpresentinfectionCountryoforiginisTHEmajorriskfactorWorldHealthOrganization.HepatitisBFactSheet.CentersforDiseaseControlandPrevention.CDCHealthInformationforInternationalTravel2023.NewYork:OxfordUniversityPress;2023.PrevalenceofHBsAgHigh≥8%Intermediate2%to7%Low2%

慢性乙肝病毒感染自然史YimHJ,etal.Hepatology.2023;43:S173-S181.HBeAg+ HBeAg- HBeAb+ImmuneClearanceImmunotoleranceALTHBVDNAMos-YrsImmuneControl(Nonreplicative)HBsAg+ HBsAg-HBsAb+InfectionMos-Yrs5-30Yrs

YimHJ,etal.Hepatology.2023;43:S173-S181.ImmuneClearanceImmunotoleranceALTHBVDNAMos-YrsHBsAg+ HBsAg-HBsAb+InfectionMos-Yrs5-30Yrs慢性乙肝病毒感染自然史MostOncologyPatientsNormalALTLow/undetectableHBVDNAHBsAg+andHBeAg-orHBsAg-,anti-HBc+ImmuneControl(Nonreplicative)

HBV能被清除吗?Immunecontrol—notclearance“ResolvedHBV”amisnomer—stillHBVDNAinlivercccDNAWerle-LapostolleB,etal.Gastroenterology.2023;126:1750-1758.

HBV能被清除吗?Immunecontrol—notclearance“ResolvedHBV”amisnomer—stillHBVDNAinlivercccDNAWerle-LapostolleB,etal.Gastroenterology.2023;126:1750-1758.

HBV能被清除吗?Immunecontrol—notclearance“ResolvedHBV”amisnomer—stillHBVDNAinliverTcellTcellTcellcccDNAWerle-LapostolleB,etal.Gastroenterology.2023;126:1750-1758.

免疫克制旳后果ImmunecontrolcanbelostImmune-mediatedliverdamagewithimmunereconstitutionHIVSteroidsChemotxTcellTcellTcellcccDNAWerle-LapostolleB,etal.Gastroenterology.2023;126:1750-1758.

免疫克制旳后果ImmunecontrolcanbelostImmune-mediatedliverdamagewithimmunereconstitutionHIVSteroidsChemotxTcellTcellTcellcccDNAWerle-LapostolleB,etal.Gastroenterology.2023;126:1750-1758.

HBV再激活5-30YrsMos-YrsInfectionImmunotoleranceImmuneClearanceHBeAg+ HBeAg-HBeAb+Mos-YrsALTHBVDNAHBeAg+HoofnagleJH.Hepatology.2023;49(5suppl):S156-S165.

HBV再激活5-3