x-ray repair cross complementing protein 1 in base excision repairx射线修复1基本切除修复交叉补充蛋白质.pdf

Int. J. Mol. Sci. 2012, 13, 17210-17229; doi:10.3390/ijms131217210 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair Audun Hanssen-Bauer , Karin Solvang-Garten , Mansour Akbari and Marit Otterlei * Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway; E-Mails: audunhb@ (A.H.-B.); karin.solvang-garten@ntnu.no (K.S.-G.) Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 N, Denmark; E-Mail: akbari@sund.ku.dk * Author to whom correspondence should be addressed; E-Mail: marit.otterlei@ntnu.no; Tel.: +47 Fax: +47 Received: 9 November 2012; in revised form: 6 December 2012 / Accepted: 7 December 2012 / Published: 17 December 2012 Abstract: X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways. XRCC1 also interacts with itself and rapidly accumulates at sites of DNA damage. XRCC1 can thus mediate the assembly of large multiprotein DNA repair complexes as well as facilitate the recruitment of DNA repair proteins to sites of DNA damage. Moreover, XRCC1 is present in constitutive DNA repair complexes, some of which associate with the replication machinery.