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the fecal viral flora of wild rodents野生啮齿动物的粪便病毒植物.pdf

发布:2017-09-11约11.38万字共16页下载文档
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The Fecal Viral Flora of Wild Rodents 1,2 1,2,3 4 5 6 Tung G. Phan , Beatrix Kapusinszky , Chunlin Wang , Robert K. Rose , Howard L. Lipton , Eric L. Delwart1,2* 1 Blood Systems Research Institute, San Francisco, California, United States of America, 2 Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California, United States of America, 3 Department of Viral Diagnostics, National Center for Epidemiology, Budapest, Hungary, 4 Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America, 5 Department of Biological Sciences, Old Dominion University, Norfolk, Virginia, United States of America, 6 Department of Neurology and Microbiology-Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America Abstract The frequent interactions of rodents with humans make them a common source of zoonotic infections. To obtain an initial unbiased measure of the viral diversity in the enteric tract of wild rodents we sequenced partially purified, randomly amplified viral RNA and DNA in the feces of 105 wild rodents (mouse, vole, and rat) collected in California and Virginia. We identified in decreasing frequency sequences related to the mammalian viruses families Circoviridae, Picobirnaviridae, Picornaviridae, Astroviridae, Parvoviridae, Papillomaviridae, Adenoviridae, and Coronaviridae. Seventeen small circular DNA genomes containing one or two replicase genes distantly related to the Circoviridae representing several potentially new viral families were characterized. In the Picornaviridae family two new candidate genera as well as a close genetic relative of the human pa
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