the fecal viral flora of wild rodents野生啮齿动物的粪便病毒植物.pdf
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The Fecal Viral Flora of Wild Rodents
1,2 1,2,3 4 5 6
Tung G. Phan , Beatrix Kapusinszky , Chunlin Wang , Robert K. Rose , Howard L. Lipton , Eric L.
Delwart1,2*
1 Blood Systems Research Institute, San Francisco, California, United States of America, 2 Department of Laboratory Medicine, University of California at San Francisco, San
Francisco, California, United States of America, 3 Department of Viral Diagnostics, National Center for Epidemiology, Budapest, Hungary, 4 Division of Infectious Diseases,
Stanford University Medical Center, Stanford, California, United States of America, 5 Department of Biological Sciences, Old Dominion University, Norfolk, Virginia, United
States of America, 6 Department of Neurology and Microbiology-Immunology, University of Illinois at Chicago, Chicago, Illinois, United States of America
Abstract
The frequent interactions of rodents with humans make them a common source of zoonotic infections. To obtain an initial
unbiased measure of the viral diversity in the enteric tract of wild rodents we sequenced partially purified, randomly
amplified viral RNA and DNA in the feces of 105 wild rodents (mouse, vole, and rat) collected in California and Virginia. We
identified in decreasing frequency sequences related to the mammalian viruses families Circoviridae, Picobirnaviridae,
Picornaviridae, Astroviridae, Parvoviridae, Papillomaviridae, Adenoviridae, and Coronaviridae. Seventeen small circular DNA
genomes containing one or two replicase genes distantly related to the Circoviridae representing several potentially new
viral families were characterized. In the Picornaviridae family two new candidate genera as well as a close genetic relative of
the human pa
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