Aurora激酶抑制剂的抗肿瘤作用.pdf

‘941· 蝤鏖胜疸堂盘查2Q螋生!Q旦筮!垒鲞筮!Q翅垦蝤旦曼丝鱼!世型Q里!殳!!＆：坐!：兰Q塑：!旦!：!垒：塑!：!Q ·综述与讲座· Aurora激酶抑制剂的抗肿瘤作用半 510060广州中山大学肿瘤防治中心华南肿瘤学国家重点实验室 夏良平，周菲菲，刘 强 【摘要】 显示了很强的抗肿瘤能力。部分抑制剂都进入了I期临床实验。Aurora激酶抑制剂与传统的化疗药物如紫杉类药物、替莫唑 或替莫唑胺化疗的敏感性。 【关键词】 Aurora激酶抑制剂；放射治疗； 化学治疗；联合作用； p53 中图分类号：R730．1文献标识码：A 文章编号：1009—0460(2009)10—0941—05 Theanticancerroleofaurorakinaseinhibitors XIA inSouth Liang-ping，ZHOUFei-fei，LlUQiang．StateKeyLaboratoryof China，CancerCenter， Oncology SunYat—sen 510060。China University．Guangzhou kinaseinhibitorsarenew ofthe of aurorakinaseshave COl- 【Abstract】Aurora memberfamilytargetedagents．Notonly strong relationwithtumorbutalsotheantieaneerofaurorakinase demonstratedin ofcancer efficacy inhibitors，硒monotherapy，werevariety oftheinhibitorsare I clinicaltrails．The r鹅earchincancercelllinesshowedthatthe types，even，some ongoingphase emerging combinationofaurorakinaseinhibitorsandtraditional suchas VP-16Was chemotherapyagents moreeffectivethantheeachtreatmentalone．Aurorakinaseinhibitorscanoverridethechemoresistaneecaused kinase byE2；aurora inhibitom咖enhancethe of to roleofaurolakinaseinhibitors onthe cancer．However．the sensitivityradiotherapy dependsstrongly thecancerceHswithmutatedorno-functionaleaRbenefitfromthecombination orTMZ． p53status：only p53 p53 w汕radiotherapy kinase 【KeyWords】Aurorainhibitor；Rad