unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids独特的细胞特定类型交界复合物在血管内皮的人类和大鼠肝血窦.pdf

Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids ´ 1 . 1. 2 1 1 Cyrill Geraud * , Konstantin Evdokimov , Beate K. Straub , Wiebke K. Peitsch , Alexandra Demory , ¨ 1 1 1 3 4,5 Yvette Dorflinger , Kai Schledzewski , Astrid Schmieder , Peter Schemmer , Hellmut G. Augustin , Peter Schirmacher2, Sergij Goerdt1 1 Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, and Center of Excellence in Dermatology, Mannheim, Germany, 2 Department of Pathology, University Clinic Heidelberg, University of Heidelberg, Germany, 3 Department of General and Transplantation Surgery, Ruprecht-Karls-University, Heidelberg, Germany, 4 Joint Research Division Vascular Biology, German Cancer Research Center, Heidelberg, Germany, 5 Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany Abstract Liver sinusoidal endothelium is strategically positioned to control access of fluids, macromolecules and cells to the liver parenchyma and to serve clearance functions upstream of the hepatocytes. While clearance of macromolecular debris from the peripheral blood is performed by liver sinusoidal endothelial cells (LSECs) using a delicate endocytic receptor system featuring stabilin-1 and -2, the mannose receptor and CD32b, vascular permeability and cell trafficking are controlled by transcellular pores, i.e. the fenestrae, and by intercellular junctional complexes. In contrast