soluble isoforms of vascular endothelial growth factor are predictors of response to sunitinib in metastatic renal cell carcinomas可溶性血管内皮生长因子的亚型预测应对舒尼替转移性肾细胞癌.pdf

Soluble Isoforms of Vascular Endothelial Growth Factor Are Predictors of Response to Sunitinib in Metastatic Renal Cell Carcinomas 1,2 2 3 4 Bernard Paule , Laurence Bastien , Emmanuelle Deslandes , Olivier Cussenot , Marie-Pierre 5 2 ¨ 1 3 2 Podgorniak , Yves Allory , Benyoussef Naımi , Raphael Porcher , Alexandre de La Taille , Suzanne Menashi6, Fabien Calvo1,5,7, Samia Mourah1,5* ˆ ´ 1 Inserm, UMRS 940, Paris, France, 2 AP-HP, Hopital Henri Mondor, Department of Urology, Inserm-U841Eq07, Creteil, France, 3 Inserm, U717, Department of Biostatistics ´ ˆ ˆ and Medical Data Processing, Universite Paris 7, Hopital Saint-Louis AP-HP, Paris, France, 4 AP-HP, Hopital Tenon, Department of Urology and the CeRePP National Group, ˆ ´ ´ ´ Paris, France, 5 AP-HP, Hopital Saint-Louis, Laboratory of Pharmacology, Paris, France, 6 CNRS-UMR 7149, Universite Paris Est, Creteil, France, 7 Universite Paris 7- Denis Diderot, Paris, France Abstract Background: Angiogenesis is the target of several agents in the treatment of malignancies, including renal cell carcinoma (RCC). There is a real need for surrogate biomarkers that can predict selection of patients who may benefit from antiangiogenic therapies, prediction of disease outcome and which may improve the knowledge regarding m