麝香通心滴丸联合“新四联”方案对老年射血分数保留的心力衰竭患.docx

麝香通心滴丸联合“新四联”方案对老年射血分数保留的心力衰竭患者的疗效分析

[中图分类号]R541.6；R256.2[文献标识码]A[DOI]10.3969/j.issn.1673-9701.2025.07.013

AnalysisofcurativeeffectofShexiangTongxindroppingpillscombinedwith“Quadrupletherapy”onelderlypatientswithheartfailurewithpreservedejectionfraction

LOUKai1，ZHANGJichen2，HAOYing3，LIRujun4

1.DepartmentofEmergency，TaizhouFirstPeople’sHospital，Taizhou318020，Zhejiang，China;2.DepartmentofCardiothoracicSurgery，TaizhouFirstPeople’sHospital，Taizhou318020，Zhejiang，China;3.DepartmentofGeriatrics，TaizhouFirstPeople’sHospital，Taizhou318020，Zhejiang，China;4.DepartmentofCardiology，AffiliatedHospitalofYangzhouUniversity，Yangzhou225012，Jiangsu，China

[Abstract]ObjectiveToevaluatetheclinicalefficacyofShexiangTongxindroppingpillscombinedwith“Quadrupletherapy”inelderlypatientswithheartfailurewithpreservedejectionfraction（HFpEF）.MethodsAtotalof193elderlyHFpEFpatientsadmittedtoAffiliatedHospitalofYangzhouUniversityfromJanuarytoJune2022wereselectedasstudyobjects，andweredividedintoobservationgroup（97cases）andcontrolgroup（96cases）accordingtorandomnumbertablemethod.Thecontrolgroupwastreatedwithsacubitrilvalsartansodiumtablets+dapagliflozintablets+metoprololtartratetablets+spironolactonetablets，andtheobservationgroupwastreatedwithShexiangTongxindroppingpillsonthebasisofcontrolgrouptreatment，andbothgroupsweretreatedfor6months.Thechangesofcardiacfunctionindexes，serummyocardialinjurymarkers，endothelialfunctionandinflammationindexesbeforeandaftertreatmentwerecomparedbetweentwogroups.Theaveragelengthofhospitalization，readmissionratewithin30daysandtheeffectiverateoftreatmentwereanalyzed.After6monthsoffollow-up，the6-minutewalktest，6-monthreadmissionrateandtheincidenceofmajoradversecardiovascularevent（MACE）werecomparedbetweentwogroups.ResultsAfter30daysoftreatment，thetotaleffectiverateofobservationgroupwassignificantlyhigherthanthatnbsp;ofcontrolgroup（93.8%vs.90.6%，c2=3.982，P=0.031）.After30daysoftreatment，leftventricularenddiastolicdiameter，leftventricularendsystolicdiameter，N-terminalpro-brainnat